Olfactory dysfunction in neurodegenerative diseases: is there a common pathological substrate?

The Lancet Neurology

DOI: http://dx.doi.org/10.1016/S1474-4422(17)30123-0
Published: June 2017

Prof. Richard L Doty, PhD

In patients with neurodegenerative diseases, there is a spectrum of smell dysfunction ranging from severe loss, as seen in Alzheimer’s disease and Parkinson’s disease, to relatively little loss, as seen in progressive supranuclear palsy. Given the ubiquitous but varying degrees of olfactory dysfunction among such diseases, it is conceivable that differential disruption of a common primordial neuropathological substrate causes these differences in olfactory function.

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