Parkinson Disease Propagation Using MRI Biomarkers and Partial Least Squares Path Modeling
Neurology Journal
Fecha de publicación: December 4, 2020
DOI: https://doi.org/10.1212/WNL.0000000000011155
Autores: Nadya Pyatigorskaya, Lydia Yahia-Cherif, Romain Valabregue, Rahul Gaurav, Fatma Gargouri, Claire Ewenczyk, Cecile Gallea, Sara Fernandez-Vidal, Isabelle Arnulf, Marie Vidailhet, Stephane Lehericy.
Background: The classic Braak neuropathologic staging model in Parkinson disease (PD) suggests that brain lesions progress from the medulla oblongata to the cortex. An alternative model in which neurodegeneration first occurs in the cortex has also been proposed. These 2 models may correspond to different patient phenotypes. To test these 2 models and to investigate whether they were influenced by the presence of REM sleep behavior disorder (RBD), we used multimodal MRI and partial least squares path modeling (PLS-PM) assuming that patients with RBD followed distinct neurodegeneration pattern.
