Parkinson’s disease determinants, prediction and gene–environment interactions in the UK Biobank
Journal of Neurology, Neurosurgery & Psychiatry
Fecha: 15 September, 2020
Autores: Benjamin Meir Jacobs, Daniel Belete, Jonathan Bestwick, Cornelis Blauwendraat, Sara Bandres-Ciga, Karl Heilbron, Ruth Dobson, Mike A Nalls, Andrew Singleton, John Hardy, Gavin Giovannoni, Andrew John Lees, Anette-Eleonore Schrag, Alastair J Noyce.
Background: To systematically investigate the association of environmental risk factors and prodromal features with incident Parkinson’s disease (PD) diagnosis and the interaction of genetic risk with these factors. To evaluate whether existing risk prediction algorithms are improved by the inclusion of genetic risk scores.