Polygenic Risk Score Contribution to Psychosis Prediction in a Target Population of Persons at Clinical High Risk

American Journal of Psychiatry

Fecha de publicación: 12 November 2019

DOI: https://doi.org/10.1176/appi.ajp.2019.18060721

Autores: Diana O. Perkins, M.D., M.P.H., Loes Olde Loohuis, Ph.D., Jenna Barbee, B.S., John Ford, M.S., Clark D. Jeffries, Ph.D., Jean Addington, Ph.D., Carrie E. Bearden, Ph.D., Kristin S. Cadenhead, M.D., Tyrone D. Cannon, Ph.D., Barbara A. Cornblatt, Ph.D., Daniel H. Mathalon, et al.

Background: The 2-year risk of psychosis in persons who meet research criteria for a high-risk syndrome is about 15%−25%; improvements in risk prediction accuracy would benefit the development and implementation of preventive interventions. The authors sought to assess polygenic risk score (PRS) prediction of subsequent psychosis in persons at high risk and to determine the impact of adding the PRS to a previously validated psychosis risk calculator.

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