Presurgical thalamic “hubness” predicts surgical outcome in temporal lobe epilepsy

Neurology Journal

Published online: May 17, 2017
DOI: http:/​/​dx.​doi.​org/​10.​1212/​WNL.​0000000000004035

AutoresXiaosong He, PhD, Gaelle E. Doucet, PhD, Dorian Pustina, PhD, Michael R. Sperling, MD, Ashwini D. Sharan, MD and Joseph I. Tracy, PhD

Objective: To characterize the presurgical brain functional architecture presented in patients with temporal lobe epilepsy (TLE) using graph theoretical measures of resting-state fMRI data and to test its association with surgical outcome.
Methods: Fifty-six unilateral patients with TLE, who subsequently underwent anterior temporal lobectomy and were classified as obtaining a seizure-free (Engel class I, n = 35) vs not seizure-free (Engel classes II–IV, n = 21) outcome at 1 year after surgery, and 28 matched healthy controls were enrolled. On the basis of their presurgical resting-state functional connectivity, network properties…

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