Progression of cognitive and behavioural impairment in early amyotrophic lateral sclerosis
Journal of Neurology, Neurosurgery & Psychiatry
Fecha de publicación: 13 May 2020
Autores: Emma Beeldman, Rosanne Govaarts, Marianne de Visser, Michelle Klein Twennaar, Anneke J van der Kooi, Leonard H van den Berg, Jan H Veldink, Yolande A L Pijnenburg, Rob J de Haan, Ben A Schmand, Joost Raaphorst
Background: Whether cognitive and behavioural impairment in amyotrophic lateral sclerosis (ALS) is progressive is unknown. The majority of longitudinal studies (summarised in online supplementary material) are characterised by stable test results, high attrition and under-representation of patients with a short disease duration. The aim of this study was to determine progression of cognitive and behavioural impairment in patients with early symptomatic ALS.