PTSD Psychotherapy Outcome Predicted by Brain Activation During Emotional Reactivity and Regulation

The American Journal of Psychiatry

Fecha de publicación: December 2017


Autores:  Gregory A. Fonzo, Ph.D., Madeleine S. Goodkind, Ph.D., Desmond J. Oathes, Ph.D., Yevgeniya V. Zaiko, B.A., Meredith Harvey, B.A., Kathy K. Peng, M.A., M. Elizabeth Weiss, Ph.D., Allison L. Thompson, Ph.D., Sanno E. Zack, Ph.D., Steven E. Lindley, M.D., Ph.D., Bruce A. Arnow, Ph.D., Booil Jo, Ph.D., James J. Gross, Ph.D., Barbara O. Rothbaum, Ph.D., Amit Etkin, M.D., Ph.D.

Background: Exposure therapy is an effective treatment for posttraumatic stress disorder (PTSD), but many patients do not respond. Brain functions governing treatment outcome are not well characterized. The authors examined brain systems relevant to emotional reactivity and regulation, constructs that are thought to be central to PTSD and exposure therapy effects, to identify the functional traits of individuals most likely to benefit from treatment.


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