A quantitative meta-analysis of olfactory dysfunction in mild cognitive impairment

Journal of Neurology, Neurosurgery & Psychiatry

Volume 88, Issue 3, 17 February 2017

David R Roalf, Madelyn J Moberg, Bruce I Turetsky, Laura Brennan, Sushila Kabadi, David A Wolk, Paul J Moberg


Background The connection between Alzheimer’s disease (AD) and olfactory deficits is well documented and further, alterations in olfactory functioning may signal declines in functions associated with dementia. The aim of the present comprehensive meta-analysis was to investigate the nature of olfactory deficits in mild cognitive impairment (MCI).

Methods Articles were identified through computerised literature search from inception to 30 June 2016 using PubMed, MEDLINE and PsychInfo databases. In order to control for differences in sample size during effect size computation, studies were weighted according to their inverse variance estimates.

Results 31 articles (62 effects) were identified, which included 1993 MCI patients and 2861 healthy older adults (HOA). Included studies contrasted odour identification, discrimination, detection threshold and/or memory between cases and controls…

Seguir leyendo

Enviar comentario