Journal of Neurology, Neurosurgery & Psychiatry
Volume 88, Issue 5, Published online 4 May 2017
Anand Tekriwal, Drew S Kern, Jean Tsai, Nuri F Ince, Jianping Wu, John A Thompson, Aviva Abosch, Author affiliations
Abstract
Rapid eye movement (REM) sleep behaviour disorder (RBD) is characterised by complex motor enactment of dreams and is a potential prodromal marker of Parkinson’s disease (PD). Of note, patients with PD observed during RBD episodes exhibit improved motor function, relative to baseline states during wake periods. Here, we review recent epidemiological and mechanistic findings supporting the prodromal value of RBD for PD, incorporating clinical and electrophysiological studies…
