Safety and efficacy of sonothrombolysis for acute ischaemic stroke: a multicentre, double-blind, phase 3, randomised controlled trial

The Lancet Neurology

Fecha de publicación: April 2019


Autores: Andrei V Alexandrov, MD., Martin Köhrmann, MD., Lauri Soinne, MD., Georgios Tsivgoulis, MD., Andrew D Barreto, MD., Andrew M Demchuk, MD., et al.

Background: Pulsed-wave ultrasound increases the exposure of an intracranial thrombus to alteplase (recombinant tissue plasminogen activator), potentially facilitating early reperfusion. We aimed to ascertain if a novel operator-independent transcranial ultrasound device delivering low-power high-frequency ultrasound could improve functional outcome in patients treated with alteplase after acute ischaemic stroke.

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