Second-generation antipsychotic drugs and short-term somatic serious adverse events: a systematic review and meta-analysis

The Lancet Psychiatry

Fecha de publicación: 15 July 2019


Autores: Johannes Schneider-Thoma, MD., Orestis Efthimiou, PhD., Irene Bighelli, PhD., Carola Dörries., Maximilian Huhn, MD., Marc Krause, MA., Leonie Reichelt., Hannah Röder., Prof Toshi A Furukawa, MD., Prof John M Davis, MD., Stefan Leucht, MD.

Background: Antipsychotic drugs might cause acutely occurring, serious side-effects and thus contribute to the increased physical morbidity and mortality observed in patients with severe mental health disorders. We examined this hypothesis by doing a meta-analysis of International Conference on Harmonisation-Good Clinical Practice-defined serious adverse events occurring in placebo-controlled trials of antipsychotics.

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