Sensory cortex hyperexcitability predicts short survival in amyotrophic lateral sclerosis

Neurology Journal

Fecha de publicación: March 30, 2018

DOI: doi.org/10.1212/WNL.0000000000005424

Autores: Toshio Shimizu, Kota Bokuda, Hideki Kimura, Tsutomu Kamiyama, Yuki Nakayama, Akihiro Kawata, Eiji Isozaki, Yoshikazu Ugawa

Background: Methods A total of 145 patients with sporadic ALS and 73 healthy control participants were studied. We recorded compound muscle action potential and sensory nerve action potential of the median nerve and the median nerve somatosensory evoked potential (SEP), and we measured parameters, including onset-to-peak amplitude of N13 and N20 and peak-to-peak amplitude between N20 and P25 (N20p-P25p).