A specific pattern of gray matter atrophy in Alzheimer’s disease with depression

Journal of Neurology

Fecha de publicación: 30 August 2017

DOI: https://doi.org/10.1007/s00415-017-8603-z

Autores: Efstratios Karavasilis Theodore P. ParthimosJohn D. PapatriantafyllouSokratis G. PapageorgiouGeorge KapsasAndrew C. PapanicolaouIoannis Seimenis

Objective: Considering the high incidence of depressive symptoms in Alzheimer’s disease (AD), we conducted a large-sample study to investigate the pattern of gray matter (GM) abnormalities that differentiates depressive from non-depressive AD patients. We included 201 AD patients who underwent MRI assessment and categorized them into depressive and non-depressive subgroups based on the Geriatric Depression Scale (GDS; cut-off score: ≤9). We performed whole-brain voxel-based morphometry analysis in 173 patients after MRI quality control and used between-group comparisons and regression analysis models to analyze the volumetric data controlling for nuisance variables.


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