T cells and Parkinson’s disease

The Lancet Neurology

Fecha de publicación: 11 August 2017

DOI: http://dx.doi.org/10.1016/S1474-4422(17)30276-4

Autores: R Lee Mosley, Howard E Gendelman

Objective: Although effector and regulatory T-cell populations can promote either neurotoxic or neuroprotective effects in the control of the brain’s microenvironment, how these cells are induced during Parkinson’s disease is not known.1, 2 David Sulzer and colleagues3 have reported a functional role of α-synuclein in immune tolerance. The authors posit that lymphocyte populations emerge from α-synuclein induction of autoreactive CD4+ and CD8+ T cells.


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