Targeting the centromedian thalamic nucleus for deep brain stimulation

Journal of Neurology, Neurosurgery & Psychiatry

Fecha de publicación: 24 January 2020


Autores: Aaron E L Warren, Linda J Dalic, Wesley Thevathasan, Annie Roten, Kristian J Bulluss, John Archer

Background: Deep brain stimulation (DBS) of the centromedian thalamic nucleus (CM) is an emerging treatment for multiple brain diseases, including the drug-resistant epilepsy Lennox-Gastaut syndrome (LGS). We aimed to improve neurosurgical targeting of the CM by: (1) developing a structural MRI approach for CM visualisation, (2) identifying the CM’s neurophysiological characteristics using microelectrode recordings (MERs) and (3) mapping connectivity from CM-DBS sites using functional MRI (fMRI).

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