The cognitive profile of behavioural variant FTD and its similarities with ALS: a systematic review and meta-analysis

Journal of Neurology, Neurosurgery & Psychiatry

Fecha de publicación: 9 February 2018


Autores: Emma Beeldman, Joost Raaphorst, Michelle Klein Twennaar, Rosanne Govaarts, Yolande A L Pijnenburg, Rob J de Haan, Marianne de Visser, Ben A Schmand

Background: Approximately 30% of patients with amyotrophic lateral sclerosis (ALS) have cognitive impairment and 8%–14% fulfil the criteria for behavioural variant frontotemporal dementia (bv-FTD). The cognitive profiles of ALS and bv-FTD have been reported to be comparable, but this has never been systematically investigated. We aimed to determine the cognitive profile of bv-FTD and examine its similarities with that of ALS, to provide evidence for the existence of a cognitive disease continuum encompassing bv-FTD and ALS. 


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