The neurodegenerative prodrome in multiple sclerosis

The Lancet Neurology
Volume 16, No. 6, p413–414, June 2017

Gavin Giovannoni

All neurodegenerative diseases have a preclinical phase during which damage occurs. This phase might be associated with subtle symptoms and signs that do not warrant a diagnosis—ie, a prodrome. Identification of a prodrome is important because it might allow clinicians to diagnose disease earlier. With the emergence of disease-modifying therapies, identification of patients in the preclinical phase of the disease might improve disease outcomes…

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