The Overlapping Neurobiology of Induced and Pathological Anxiety: A Meta-Analysis of Functional Neural Activation

The American Journal of Psychiatry

Fecha de publicación: 15 October 2020


Autores: Rebecca J. Evans-Polce, Ph.D., Luisa Kcomt, Ph.D., M.S.W., Philip T. Veliz, Ph.D., Carol J. Boyd, Ph.D., R.N., Sean Esteban McCabe, Ph.D., M.S.W.

Background: Although anxiety can be an adaptive response to unpredictable threats, pathological anxiety disorders occur when symptoms adversely affect daily life. Whether or not adaptive and pathological anxiety share mechanisms remains unknown, but if they do, induced (adaptive) anxiety could be used as an intermediate translational model of pathological anxiety to improve drug development pipelines. The authors therefore compared meta-analyses of functional neuroimaging studies of induced and pathological anxiety.

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