The prion model for progression and diversity of neurodegenerative diseases

Journal of Neurology, Neurosurgery & Psychiatry
Volume 16, No. 4, p323–332, April 2017

Barbara E Stopschinski, MD, Dr. Marc I Diamond, MD



The neuropathology of different neurodegenerative diseases begins in different brain regions, and involves distinct brain networks. Evidence indicates that transcellular propagation of protein aggregation, which is the basis of prion disease, might underlie the progression of pathology in neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease.


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