The relationship between cortical glutamate and striatal dopamine in first-episode psychosis: a cross-sectional multimodal PET and magnetic resonance spectroscopy imaging study

The Lancet Psychiatry

Fecha de publicación: 20 september 2018


Autores: Laurie J Hannigan, PhD., Espen Moen Eilertsen, PhD., Line C Gjerde, PhD., Ted Reichborn-Kjennerud, MD., Prof Thalia C Eley, PhD., Fruhling V Rijsdijk, PhD., Eivind Ystrom, PhD., Tom A McAdams, PhD 

Background: The pathophysiology of psychosis is incompletely understood. Disruption in cortical glutamatergic signalling causing aberrant striatal dopamine synthesis capacity is a proposed model for psychosis, but has not been tested in vivo. We therefore aimed to test the relationship between cortical glutamate concentrations and striatal dopamine synthesis capacity, and psychotic symptoms.

Seguir leyendo

Enviar comentario