Understanding neurodegeneration after traumatic brain injury: from mechanisms to clinical trials in dementia

Journal of Neurology, Neurosurgery & Psychiatry

Fecha de publicación: 24 September 2019

DOI: http://dx.doi.org/10.1136/jnnp-2017-317557

Autores: Neil SN Graham, David J Sharp.

Background: Traumatic brain injury (TBI) leads to increased rates of dementia, including Alzheimer’s disease. The mechanisms by which trauma can trigger neurodegeneration are increasingly understood. For example, diffuse axonal injury is implicated in disrupting microtubule function, providing the potential context for pathologies of tau and amyloid to develop.