Understanding neurodegeneration after traumatic brain injury: from mechanisms to clinical trials in dementia
Journal of Neurology, Neurosurgery & Psychiatry
Fecha de publicación: 24 September 2019
Autores: Neil SN Graham, David J Sharp.
Background: Traumatic brain injury (TBI) leads to increased rates of dementia, including Alzheimer’s disease. The mechanisms by which trauma can trigger neurodegeneration are increasingly understood. For example, diffuse axonal injury is implicated in disrupting microtubule function, providing the potential context for pathologies of tau and amyloid to develop.