Use of schizophrenia and bipolar disorder polygenic risk scores to identify psychotic disorders
The British Journal of Psychiatry
Fecha de publicación: 16 august 2018
DOI: https://doi.org/10.1192/bjp.2018.89
Autores: Maria Stella Calafato, Johan H. Thygesen, Siri Ranlund, Eirini Zartaloudi, Wiepke Cahn, Benedicto Crespo-Facorro, Álvaro Díez-Revuelta, Marta Di Forti, Genetic Risk and Outcome of Psychosis (GROUP) consortium, Mei-Hua Hall, Conrad Iyegbe, Assen Jablensky, Rene Kahn, Luba Kalaydjieva, Eugenia Kravariti, Kuang Lin, Colm McDonald, Andrew M. McIntosh, Andrew McQuillin, Psychosis Endophenotypes International Consortium (PEIC) , Marco Picchioni, Dan Rujescu, Madiha Shaikh, Timothea Toulopoulou, Jim Van Os, Evangelos Vassos, Muriel Walshe, John Powell, Cathryn M. Lewis, Robin M. Murray, Elvira Bramon and Wellcome Trust Case Control Consortium 2 (WTCCC2)
Background: There is increasing evidence for shared genetic susceptibility between schizophrenia and bipolar disorder. Although genetic variants only convey subtle increases in risk individually, their combination into a polygenic risk score constitutes a strong disease predictor.
