Weight Trajectory over 20 Years and Likelihood of Mild Cognitive Impairment or Dementia Among Older Women

Journal of American Geriatrics Society
19 December 2016

Erin S. LeBlanc MD, MPH, Joanne H. Rizzo MPA, Kathryn L. Pedula MS, Kristine Yaffe MD, Kristine E. Ensrud MD, Jane Cauley DrPH, Peggy M. Cawthon PhD, Steven Cummings MD, Teresa A. Hillier MD, MS, and for the Study of Osteoporotic Fractures (SOF) Research Group


Objectives: The association between weight change and cognition is controversial. We examined the association between 20-year weight change and cognitive function in late life.

Design: Cohort study.

Setting: Study of Osteoporotic Fractures (SOF).

Participants: One thousand two hundred eighty-nine older, community-dwelling women (mean baseline age 68 (65–81) and 88 (82–102) at cognitive testing).

Measurements: Study of Osteoporotic Fractures participants had body weight measured repeatedly over 20 years (mean 8 weights)…

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