Whole Brain White Matter Tract Deviation and Idiosyncrasy From Normative Development in Autism and ADHD and Unaffected Siblings Link With Dimensions of Psychopathology and Cognition

American Journal of Psychiatry

Fecha de publicación: 17 de marzo de 2021

DOI: https://doi.org/10.1176/appi.ajp.2020.20070999

Autores: Yu-Hung Tung, M.D., Hsiang-Yuan Lin, M.D., Chang-Le Chen, M.Sc., Chi-Yung Shang, M.D., Ph.D., Li-Ying Yang, M.Sc., Yung-Chin Hsu, Ph.D., Wen-Yih Isaac Tseng, M.D., Ph.D., Susan Shur-Fen Gau, M.D., Ph.D.

Background: The heterogeneity of autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) preclude definitive identification of neurobiomarkers and biological risks. High clinical overlap suggests multifaceted circuit-level alterations across diagnoses, which remains elusive. This study investigated whether individuals with ADHD or ASD and their unaffected siblings constitute a spectrum of neurodevelopmental conditions in terms of white matter etiology.