Association of hippocampal subfields, CSF biomarkers and cognition in non-demented Parkinson’s disease patients
Neurology Journal
Fecha de publicación: November 20, 2020
DOI: https://doi.org/10.1212/WNL.0000000000011224
Autores: Sara Becker, Oliver Granert, Maarten Timmers, Andrea Pilotto, Luc Van Nueten, Benjamin Roeben, Giacomo Salvadore, Wendy R. Galpern, Johannes Streffer, Klaus Scheffler, Walter Maetzler, Daniela Berg, Inga-Liepelt Scarfone
Background: To examine whether hippocampal volume loss is primarily associated with cognitive status or pathologic Amyloid-β 1–42 (Aβ42) levels, this study compared hippocampal subfield volumes between both Parkinson’s Disease (PD) patients with (PD-MCI) and without (PD-CN) cognitive impairment and between patients with low and high Aβ42 levels, in addition exploring the relationship between hippocampal subfield volumes, CSF biomarkers (Aβ42, phosphorylated and total tau), neuropsychological tests, and activities of daily living.
