Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease

Neurology Journal

Fecha de publicación: 14 september 2018

DOI: https://doi.org/10.1212/WNL.0000000000006277

Autores: Eric McDadeGuoqiao WangBrian A. GordonJason HassenstabTammie L.S. BenzingerVirginia BucklesAnne M. FaganDavid M. HoltzmanNigel J. CairnsAlison M. GoateDaniel S. MarcusJohn C. MorrisKatrina PaumierChengjie XiongRicardo AllegriSarah B. BermanWilliam KlunkJames NobleJohn RingmanBernardino GhettiMartin FarlowReisa A. SperlingJasmeer ChhatwalStephen SallowayNeill R. Graff-RadfordPeter R. SchofieldColin MastersMartin N. RossorNick C. FoxJohannes LevinMathias JuckerRandall J. Batemanfor the Dominantly Inherited Alzheimer Network

Background: To assess the onset, sequence, and rate of progression of comprehensive biomarker and clinical measures across the spectrum of Alzheimer disease (AD) using the Dominantly Inherited Alzheimer Network (DIAN) study and compare these to cross-sectional estimates.

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