The Lancet Neurology
Volume 16, No. 6, p465–477, June 2017
Phillipe D O’Brien, PhD, Lucy M Hinder, PhD, Brian C Callaghan, MD, Dr Eva L Feldman
Abstract
The high prevalence of obesity is associated with an enormous medical, social, and economic burden. The metabolic dysfunction, dyslipidaemia, and inflammation caused by obesity contribute to the development of a wide variety of disorders and effects on the nervous system. In the CNS, mild cognitive impairment can be attributed to obesity-induced alterations in hippocampal structure and function in some patients. Likewise, compromised hypothalamic function and subsequent defects in maintaining whole-body energy balance might be early events that contribute to weight gain and obesity development…
