Serum neuronal exosomes predict and differentiate Parkinson’s disease from atypical parkinsonism
Journal of Neurology, Neurosurgery & Psychiatry
Fecha de publicación: 18 June 2020
DOI: http://dx.doi.org/10.1136/jnnp-2019-322588
Autores: Cheng Jiang, Franziska Hopfner, Antigoni Katsikoudi, Robert Hein, Candan Catli, Samuel Evetts,Yongzhi Huang5, Hong Wang6, John W Ryder, Gregor Kuhlenbaeumer, et al.
Background: Parkinson’s disease is characterised neuropathologically by α-synuclein aggregation. Currently, there is no blood test to predict the underlying pathology or distinguish Parkinson’s from atypical parkinsonian syndromes. We assessed the clinical utility of serum neuronal exosomes as biomarkers across the spectrum of Parkinson’s disease, multiple system atrophy and other proteinopathies.
